Paclitaxel in combination with cisplatin is less effective for peripheral blood progenitor cell mobilization

The purpose of this study was to determine the efficacy of paclitaxel in combination with cisplatin and granulocyte-colony stimulating factor (G-CSF) for mobilization of peripheral blood progenitor cells (PBPC). Twenty-seven patients with gynecological cancer received paclitaxel and cisplatin (TP, n = 9) or other platinum-based chemotherapy (n = 18) (etoposide and cisplatin [n = 5]; cyclophosphamide, adriamycin, and cisplatin [n = 8]; or pepleomycin, etoposide, and cysplatin [n = 5]). Each combination was followed by G-CSF. The mean number of colony-forming unit granulocyte macrophage (CFU-GM)/kg and CD34+ cells/kg collected per cycle was 1.2 x 105 and 0.8 x 106 after the TP regimen, compared with 2.6 x 105 (P < 0.05) and 2.0 x 106 for patients who received other platinum-based chemotherapy. The CFU-GM target yield (>/=1.0 x 105/kg) was achieved in 56% and 83% patients in the TP and comparison group, respectively. With the TP regimen, a younger age (