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Octreotide induced remission of a refractory small cell carcinoma of the endometrium
C. F. Verschraegen1, C. Matei, E. Loyer
1Section of Gynecology Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; Department of Radiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA; Department of Pathology, St. Luke Episcopal Hospital, Houston, Texas, USA.
Abstract:
This is the first report of remission obtained with octreotide in a woman diagnosed with recurrent small cell carcinoma of the endometrium with neuroendocrine features, refractory to a combination of etoposide, cisplatin, and radiation therapy. Stabilization of disease was obtained with a combination of tamoxifen and leuprolide depot. Regression of disease was then achieved by the addition of octreotide. The use of octreotide as an antitumor agent is reviewed.