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Allergic Reactions

Allergic Reactions

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma III: Clinical Manifestations

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jul 7, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Cockroach allergens and asthma.

L K Arruda¹, L D Vailes, V P Ferriani

¹Departments of Pediatrics and Cell and Molecular Biology, University of São Paulo School of Medicine of Ribeirão Preto, Brazil.

The Journal of Allergy and Clinical Immunology

|March 10, 2001

Summary

This summary is machine-generated.

Cockroach allergens trigger asthma and allergies, particularly in vulnerable populations. Reducing exposure through integrated pest management and education is key to controlling this public health issue.

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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Area of Science:

Environmental Health
Allergology
Immunology

Background:

Cockroach infestation is a significant environmental factor linked to asthma and allergies globally.
Exposure to cockroach allergens, especially early in life, increases asthma morbidity, disproportionately affecting lower socioeconomic and minority groups.
Key cockroach allergens include Bla g 2, Bla g 4, Bla g 5, Bla g 1, Per a 1, and tropomyosin, with structural similarities to other allergens causing oral allergy syndrome.

Purpose of the Study:

To investigate the role of cockroach allergens in asthma and allergy.
To explore the development and application of recombinant cockroach allergens for research and potential therapeutic strategies.
To establish exposure levels for allergic sensitization and evaluate abatement strategies for cockroach allergens.

Main Methods:

Characterization of cockroach allergen structures and production of recombinant allergens.
Environmental monitoring of Bla g 1 and Bla g 2 levels to determine sensitization thresholds.
Assessment of integrated pest management strategies, including professional insecticide application and household cleaning.

Main Results:

Recombinant cockroach allergens are available for mechanistic studies and therapeutic development.
Environmental measurements have defined exposure levels associated with allergic sensitization.
Sustained reduction of cockroach allergen levels is challenging but achievable through combined professional pest control and rigorous cleaning.

Conclusions:

Cockroach-induced asthma is a major public health concern, especially for populations with low treatment adherence.
Integrated strategies involving patient education, housing improvements, and advanced environmental and immunologic treatments are crucial for reducing cockroach-induced asthma prevalence.