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Central venous device-related infection and thrombosis in patients treated with moderate dose continuous-infusion

M E Eastman1, M Khorsand, D G Maki

  • 1Department of Medicine, University of Wisconsin, Madison, WI 53792, USA.

Cancer
|March 10, 2001
PubMed
Abstract

Insights

Central venous device-related infections and thrombosis are significant risks during moderate-dose interleukin-2 (IL-2) therapy. Low-dose warfarin did not prevent thrombosis, and infections were linked to immunotherapy type and thrombosis.

Area of Science:

  • Oncology
  • Immunotherapy
  • Infectious Disease

Background:

  • Moderate-dose continuous-infusion interleukin-2 (IL-2) is used for metastatic melanoma and renal cell carcinoma.
  • Central venous devices are crucial for IL-2 administration.
  • The incidence of central venous device-related bloodstream infection (DRBSI) and thrombosis (DRT) requires evaluation.

Purpose of the Study:

  • To determine the incidence of DRBSI and DRT in patients receiving moderate-dose continuous-infusion IL-2.
  • To identify risk factors associated with DRBSI and DRT.
  • To assess the efficacy of low-dose warfarin in preventing DRT.

Main Methods:

  • Retrospective review of 160 patients treated with moderate-dose continuous-infusion IL-2.
  • Analysis of central venous device complications, including DRBSI and DRT.
  • Evaluation of warfarin prophylaxis and patient characteristics.

Main Results:

  • A 13% incidence of DRBSI (2 per 1000 device-days) and a 16% incidence of DRT were observed.
  • DRBSI was associated with immunotherapy type and DRT.
  • DRT was associated with DRBSI; low-dose warfarin did not prevent thrombosis.

Conclusions:

  • DRBSI and DRT are significant complications of moderate-dose IL-2 therapy.
  • The risk of DRBSI appears lower than with high-dose IL-2.
  • The risk of DRT appears higher than in patients not receiving IL-2, and low-dose warfarin was ineffective.

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