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Related Experiment Videos

Chordoma: a cytologic study with histologic and radiologic correlation.

J P Crapanzano1, S Z Ali, M S Ginsberg

  • 1Cytology Service, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Cancer
|March 10, 2001
PubMed
Summary

Fine-needle aspiration biopsy (FNAB) accurately diagnoses chordoma, a rare spinal tumor. Key features include physaliphorous cells and myxoid background, with pleomorphism indicating dedifferentiation.

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Area of Science:

  • Oncology
  • Pathology
  • Cytopathology

Background:

  • Chordoma is a rare malignant tumor originating from the fetal notochord.
  • It typically occurs along the spinal axis.

Purpose of the Study:

  • To describe fine-needle aspiration biopsy (FNAB) findings in chordoma.
  • To correlate FNAB findings with histology and radiology.
  • To compare findings with existing literature.

Main Methods:

  • Review of 12 chordoma cases with histologic confirmation.
  • Analysis of cytologic material (smears, ThinPrep, cell blocks).
  • Review of imaging studies in seven cases and immunostains on selected specimens.

Main Results:

Related Experiment Videos

  • Eleven spinal axis and one metastatic chest wall chordoma identified.
  • Accurate chordoma diagnosis by FNAB in 10 cases.
  • Typical physaliphorous cells and myxoid background observed; pleomorphism and nuclear inclusions noted in some cases, potentially indicating dedifferentiation.

    • Conclusions:

    • Cytomorphologic features via FNAB enable accurate chordoma diagnosis.
    • Increased pleomorphism, nuclear inclusions, and multinucleation suggest dedifferentiation.
    • FNAB is a valuable tool for diagnosing chordoma and its variants.