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[Clinical experiences with monocomponent insulins].

K Bruni Bocher, A Giolitti, G L Turco

    Minerva Medica
    |March 14, 1975
    PubMed
    Summary
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    Monocomponent insulin therapy, free from protein impurities, reduces insulin antibodies in long-term diabetics. This purified insulin also shows clinical benefits for patients with high insulin needs or allergies.

    Area of Science:

    • Endocrinology
    • Immunology
    • Pharmaceutical Science

    Background:

    • Conventional therapeutic insulins contain protein impurities contributing to immunogenicity.
    • Schlichtkrull's concepts suggest these impurities, not the insulin molecule itself, cause antibody formation.
    • Previous insulin preparations were associated with significant insulin antibody levels.

    Purpose of the Study:

    • To evaluate the immunogenicity and clinical efficacy of monocomponent insulin.
    • To assess the impact of purified insulin on insulin antibody levels in diabetic patients.
    • To define clinical indications for monocomponent insulin therapy.

    Main Methods:

    • Clinical results over 3 years using Novo Monocomponent Lente Insulin.
    • Radioimmunoelectrophoretic method (Hein Christiansen) to measure 125I-insulin IgG binding (insulin antibody levels).

    Related Experiment Videos

  • Comparison of antibody levels in newly diagnosed vs. long-term treated diabetics, and before/after monocomponent insulin therapy.

    • Main Results:

    • Newly diagnosed diabetics showed no significant insulin antibody production.
    • Long-term treated diabetics on monocomponent insulin tended to reduce high antibody levels.
    • Monocomponent insulin therapy yielded satisfactory clinical results in cases of high insulin requirement, allergy, and lipoatrophy.

    Conclusions:

    • Monocomponent insulin, lacking protein impurities, is less immunogenic.
    • Switching to monocomponent insulin can lower existing insulin antibody levels.
    • Monocomponent insulin therapy offers clinical advantages for specific patient groups.