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Summary
This case study details a rare quintuplet pregnancy achieved with clomiphene and HCG ovulation induction. It highlights the associated maternal complications and challenges in managing high-order multiple gestations.
Area of Science:
- Reproductive Endocrinology
- Maternal-Fetal Medicine
- Neonatology
Background:
- Ovulation induction medications like clomiphene and human chorionic gonadotropin (HCG) are used to treat infertility.
- High-order multiple gestations (triplets or more) are a known risk of such treatments.
- Multiple pregnancies present significant risks to both maternal and fetal well-being.
Purpose of the Study:
- To report the first case of quintuplet gestation in Israel following ovulation induction.
- To describe the management of associated maternal complications.
- To discuss the challenges of high-order multiple pregnancies resulting from fertility treatments.
Main Methods:
- Case report of a quintuplet pregnancy.
- Description of ovulation induction protocol using clomiphene and HCG.
- Documentation of maternal complications and their management.
- Review of literature on multiple pregnancies and ovulation induction.
Main Results:
- Successful delivery of quintuplets following ovulation induction with clomiphene and HCG.
- Pregnancy complicated by ovarian hyperstimulation syndrome, toxemia, and pruritus gravidarum.
- First reported quintuplet birth in Israel.
Conclusions:
- High-order multiple gestations require specialized obstetric and neonatal care.
- Careful patient selection and monitoring are crucial when using ovulation induction drugs.
- Managing complications of multiple pregnancies is essential for optimizing outcomes.