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Clinical characteristics of the patients with hepatitis B combining hepatitis D infection

X Gu1, Q Li, Y Wang

  • 1Infectious Disease Center of Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|March 10, 2001
PubMed

Insights

Hepatitis D virus (HDV) infection significantly increases the risk and severity of chronic hepatitis, severe hepatitis, and liver cirrhosis in patients with hepatitis B (HB). HDV may also inhibit HBV DNA replication and directly harm liver cells.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) infection is a global health concern.
  • Hepatitis D virus (HDV) is a unique satellite virus that requires HBV for replication.
  • Understanding the interplay between HBV and HDV is crucial for managing coinfections.

Purpose of the Study:

  • To investigate the pathogenesis of hepatitis D virus (HDV) infection.
  • To analyze the clinical characteristics and outcomes of patients coinfected with HBV and HDV.
  • To compare the clinical features and laboratory results of HDV-positive and HDV-negative hepatitis B patients.

Main Methods:

  • A comparative analysis of 507 patients with hepatitis B and HDV infection against 213 patients with hepatitis B alone.
  • Evaluation of hepatitis types, prognosis, clinical symptoms, and biochemical markers.
  • Analysis of hepatitis virus serological markers, including HBsAg, HBeAg, and HDAg.

Main Results:

  • HDV coinfection was associated with higher incidence and mortality rates of severe chronic hepatitis, severe hepatitis, and liver cirrhosis.
  • HDV-positive patients exhibited increased rates of bleeding, ascites, hepatic coma, and elevated ALT levels.
  • HDV infection led to a lower detection rate of HBeAg and a higher expression of HDAg, suggesting inhibition of HBV replication.

Conclusions:

  • HDV infection significantly worsens the prognosis of hepatitis B, increasing the risk of severe liver disease.
  • HDV may play a direct cytotoxic role in liver damage and disease progression.
  • HDV coinfection can suppress HBV replication, impacting viral markers like HBeAg.
Abstract

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