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Updated: Aug 18, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Insights
Pediatric renal trauma, often from blunt force, requires prompt evaluation. Early diagnosis and treatment of kidney injuries in children can salvage the kidney in 90% of cases, avoiding nephrectomy.
Area of Science:
- Pediatric Traumatology
- Urologic Imaging
- Pediatric Nephrology
Background:
- Nonpenetrating trauma frequently causes renal injuries in children.
- Pre-existing renal abnormalities are present in 10% of pediatric kidney injury cases.
- Associated injuries, particularly to the brain and spleen, occur in about 40% of cases.
Purpose of the Study:
- To outline the diagnostic approach and management of pediatric renal injuries.
- To emphasize the importance of early recognition and intervention.
Main Methods:
- Clinical suspicion based on flank tenderness and hematuria.
- Radiographic evaluation including plain roentgenograms and infusion pyelography.
- Further imaging (renal scan, retrograde pyelography, aortography) for non-visualized kidneys.
Main Results:
- Bilateral contrast visualization indicates intact renal vessels.
- Renal contusion presents as reduced contrast with compression, no extravasation.
- Extravasation signifies disruption requiring surgical repair, with 90% kidney salvage.
- Delayed diagnosis of arterial occlusion leads to kidney death.
Conclusions:
- Renal injury should be suspected in children with flank tenderness and hematuria.
- Prompt radiographic evaluation is crucial for diagnosis and management.
- Early surgical intervention can salvage kidneys in most cases, minimizing the need for nephrectomy.
Abstract:
Renal injuries due to nonpenetrating trauma are common in children. Pre-existing renal abnormalities are found in 10 per cent of children who sustain kidney injuries. Associated injuries are found in approximately 40 per cent of childhood cases. The most common serious injuries are those to the brain and the spleen. A renal injury should be suspected in every child with flank tenderness and red blood cells in the urine. If the child is unconscious, gross or microscopic hematuria may be the only clue. The amount of blood in the urine does not correlate with the severity of the injury. Plain roentgenograms and an infusion pyelogram using 2 ml of 25 per cent Hypaque per pound of body weight should be obtained as soon after injury as possible. Bilateral visualization of contrast material implies intact renal vessels. Reduction of the amount of contrast seen on the injured side with compression of the collecting system and without extravasation is characteristic of renal contusion. Evidence of a coexistent flank mass implies disruption of the renal capsule. These injuries heal without either operation or prolonged bed rest. Extravasation of contrast material beyond the renal capsule signifies disruption of the collecting system, the parenchyma, and the renal capsule. Early elective debridement, repair, and drainage results in salvage of a useful kidney in about 90 per cent of cases. Nephrectomy is seldom necessary. Failure to demonstrate any contrast material on the injured side is an indication for immediate further study by renal scanning, retrograde pyelography, or aortography. If recognized and treated promptly, some kidneys deprived of blood supply by gradual arterial occlusion secondary to an intimal tear may be salvaged, whereas delay invariably results in death of the devascularized kidney.
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