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Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription
1Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP, BP 163, F-67404 Illkirch cedex, C.U. de Strasbourg, France.
The British Journal of Nutrition
|March 10, 2001
Abstract:
The peroxisome proliferator-activated receptor gamma (PPARgamma) is nuclear receptor that controls the expression of a large number of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARgamma is bound and activated by fatty acid derivatives and prostaglandin J2. In addition, thiazolidinediones, non-steroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. This review addresses the role of PPARgamma in obesity and diabetes.