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A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
Liver transplantation in a child with severe hypercholesterolaemia in Alagille syndrome
1Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
Annals of the Academy of Medicine, Singapore
|March 13, 2001
Abstract
Introduction:
Liver transplantation is a curative treatment modality in children with end stage liver disease in Alagille syndrome.
Clinical Picture:
We report a 3-year-old child with this condition who had severe hypercholesterolaemia, pruritus and extensive xanthomatosis.
Treatment:
Liver transplantation was performed in this patient.
Outcome:
He recovered well with normalisation of his lipid profile. This procedure also resulted in resolution of the disfiguring xanthomatosis.
