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Updated: Aug 14, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
[Treatment of chronic aplastic anemia with triolandren and cyclosporin A]
1Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, 300020.
Objective:
To explore more effective regimen for chronic aplastic anemia (CAA).
Methods:
Forty-five cases of CAA were treated with triolandren (TLD) (15 cases) or TLD and cyclosporin A (CsA) (30 cases).
Results:
The response rate of TLD-CsA group (83.3%) was higher than that of TLD group (60.0%), furthermore, the recovery of bone marrow colony-forming cell (CFC) number of the responding patients was more complete and rapid in TLD-CsA group than in TLD group. Bone marrow CFC number had no significant change of all nonresponding patients in both groups.
Conclusion:
The response rate of TLD-CsA was higher than that of TLD alone, and the recovery of bone marrow CFC number of the responding patients was more complete and rapid in TLD-CsA group.
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