Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Influencing Drug Absorption: Physicochemical Parameters

Factors Influencing Drug Absorption: Physicochemical Parameters

The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
The drug's acidity or basicity is essential in determining the metabolic...

In Vitro Drug Release Testing: Overview, Development and Validation

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...

In Vitro Drug Dissolution: Alternative Methods

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuropeptide Y and tuberoinfundibular dopamine activities are altered during lactation: role of prolactin.

Endocrinology·1999

Same author

Characteristics of delayed excretion of flavonoids in human urine after administration of Shosaiko-to, a herbal medicine.

Biological & pharmaceutical bulletin·1999

Same author

A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region.

Genomics·1999

Same author

Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion.

Drug development and industrial pharmacy·1999

Same author

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

Oncogene·1999

Same author

Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity.

Oncology reports·1998

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

Published on: May 11, 2017

[Influence of fry-processing on outward character and inner quality of volatile oil containing drugs such as fructus

T Zhang¹, T Li, W Jiang

¹Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|March 13, 2001

Summary

Fry-processing traditional Chinese drugs like Fructus Viticis and Rhizoma Atractylodis Macrocephalae alters volatile oil content. This study measured oil levels before and after frying to understand processing impacts.

More Related Videos

Preparation of High-Quality Fermented Fish Product

Preparation of High-Quality Fermented Fish Product

Published on: August 23, 2019

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

Published on: May 11, 2017

Preparation of High-Quality Fermented Fish Product

Preparation of High-Quality Fermented Fish Product

Published on: August 23, 2019

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development

Published on: March 17, 2023

Area of Science:

Pharmacology
Traditional Chinese Medicine
Analytical Chemistry

Background:

Traditional Chinese medicine (TCM) processing often involves methods like frying to modify drug properties.
Volatile oils are key active components in many TCM herbs, influencing their therapeutic effects.
Understanding the impact of processing on volatile oil content is crucial for quality control in TCM.

Purpose of the Study:

To investigate the effect of fry-processing on the volatile oil content of five selected TCM herbs.
To optimize frying technology conditions for TCM preparation.
To analyze the volatile oil composition of specific herbs post-processing.

Main Methods:

Five TCM herbs (Fructus Viticis, Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Fructus Foeniculi, Fructus Aurantii) were subjected to controlled fry-processing.
Volatile oil content was quantified using an accurate volatile oil extractor before and after processing.
Gas Chromatography (GC) was employed to analyze the volatile oil composition of Rhizoma Atractylodis Macrocephalae and Fructus Aurantii.

Main Results:

Fry-processing significantly altered the volatile oil content in the studied TCM herbs.
Specific frying conditions were established and measured for optimal processing.
GC analysis provided insights into the chemical profile changes of volatile oils in Rhizoma Atractylodis Macrocephalae and Fructus Aurantii post-frying.

Conclusions:

Fry-processing is an effective method for modifying the volatile oil content of traditional Chinese drugs.
The study provides a foundation for optimizing TCM processing techniques to control active component levels.
Further research can explore the pharmacological implications of these volatile oil changes.