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[Preparation and anti-HIV activity study of baicalien and its benzylated derivatives]
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and the Peking Union Medical College, Beijing 100050.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1997
Abstract:
Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5, 6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5, 7-dihydroxyl-flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro.