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[Antisecretory effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) on perfusing rats in vivo]

R M Xu1, S R Zhang, B Y Jin

  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1997
PubMed

Insights

dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) significantly reduced gastric acid secretion in rats. This antisecretory effect was comparable to cimetidine, suggesting PG6E as a potential agent for managing acid-related conditions.

Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Gastric acid secretion plays a crucial role in digestion but dysregulation can lead to various gastrointestinal disorders.
  • Prostaglandins are known to influence gastric physiology, including acid secretion.

Purpose of the Study:

  • To investigate the antisecretory effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) in a rodent model.
  • To compare the efficacy of PG6E with a known antisecretory drug, cimetidine.

Main Methods:

  • In vivo study using perfusing rats.
  • Administration of PG6E at a dose of 0.1 mg/kg.
  • Assessment of gastric acid secretion and its modulation by histamine, pilocarpine, and pentagastrin.
  • Comparison with cimetidine at 40 mg/kg.

Main Results:

  • PG6E significantly decreased gastric acid secretion in rats.
  • PG6E effectively antagonized gastric acid secretion induced by histamine, pilocarpine, and pentagastrin.
  • The antisecretory action of PG6E was found to be similar to that of cimetidine.

Conclusions:

  • PG6E exhibits potent antisecretory properties in vivo.
  • PG6E demonstrates efficacy in antagonizing stimulated gastric acid secretion.
  • The findings suggest PG6E as a potential therapeutic agent for conditions involving excessive gastric acid production.

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