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Related Experiment Videos

Bone mineral after partial gastrectomy II.

S Aukee, E M Alhava, P Karjalainen

    Scandinavian Journal of Gastroenterology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Gastric resection surgery for peptic ulcers can lead to reduced bone mineral density, particularly in women. While biochemical markers change post-surgery, bone density loss is the primary long-term effect observed.

    Area of Science:

    • Gastroenterology
    • Orthopedics
    • Biochemistry

    Background:

    • Peptic ulcer disease often requires surgical intervention.
    • Gastric surgery can impact nutrient absorption and bone metabolism.
    • Long-term effects of gastric resection on bone health require investigation.

    Purpose of the Study:

    • To assess bone mineral content and related biochemical markers in patients with peptic ulcers.
    • To compare bone mineral density in patients who underwent different types of gastric resection and reconstruction.
    • To evaluate the correlation between biochemical markers and bone mineral density post-gastric surgery.

    Main Methods:

    • Bone mineral content was measured using the gamma ray attenuation method.
    • Serum levels of calcium, phosphorus, alkaline phosphatase, and protein were analyzed.

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  • Patients were categorized based on the extent of gastric resection (1/3 or 2/3) and reconstruction method (Billroth I or II).
  • A control group of matched age and sex was used for comparison.

    • Main Results:

    • Bone mineral density was significantly lower in patients 3.3-18 years after gastric resection compared to controls.
    • Mineral loss occurred earlier in women than in men.
    • Low serum calcium levels were frequent 3.3-8.5 years post-surgery, and serum alkaline phosphatase increased.
    • No significant difference in bone mineral density was found between patients with abnormal versus normal biochemical markers.

    Conclusions:

    • Gastric resection, regardless of reconstruction type (Billroth I or II) or vagotomy status, leads to decreased bone mineral density.
    • The observed bone mineral loss did not appear to cause clinically significant health issues in the studied patients.
    • Bone health monitoring may be warranted in patients following gastric resection surgery.