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Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits
Published on: June 2, 2019
Complete arterial revascularization in the diabetic patient--early postoperative results
O Wendler1, B Hennen, T Markwirth
1Department of Thoracic and Cardiovascular Surgery, University Hospital Homburg/Saar, Germany. chowen@med-rz.uni-sb.de
Insights
Complete arterial coronary artery bypass grafting (caCABG) is safe for diabetic patients, using skeletonized arterial grafts and the T-graft approach. Radial arteries (RA) can be used as a second graft, avoiding bilateral internal thoracic artery (ITA) harvesting.
Area of Science:
- Cardiovascular Surgery
- Diabetic Patient Management
- Arterial Grafting Techniques
Background:
- Arterial grafts offer prognostic benefits for diabetic patients undergoing coronary artery bypass grafting (CABG).
- Graft availability and sternal complications have limited the use of arterial grafts in diabetic patients.
- Complete arterial coronary artery bypass grafting (caCABG) with skeletonized grafts, radial arteries (RA), and T-graft approach may reduce perioperative risks in diabetic patients.
Purpose of the Study:
- To evaluate the safety and efficacy of caCABG in diabetic patients compared to non-diabetic patients.
- To assess the utility of skeletonized arterial grafts, RA, and T-graft approach in diabetic patients.
- To determine if caCABG in diabetic patients yields comparable outcomes to non-diabetic patients.
Main Methods:
- Retrospective analysis of perioperative data from 174 diabetic and 402 non-diabetic patients who underwent caCABG.
- Graft utilization included bilateral internal thoracic arteries (ITA) or ITA and RA.
- Comparison of patient characteristics, including incidence of 3-vessel disease and left ventricular ejection fraction.
Main Results:
- No significant differences in the need for intra-aortic balloon pump, myocardial infarction, or sternal complications between diabetic and non-diabetic groups.
- In-hospital mortality rates were comparable: 1.7% for diabetic patients versus 2.2% for non-diabetic patients.
- Diabetic patients showed a higher incidence of 3-vessel disease and lower left ventricular ejection fraction.
Conclusions:
- caCABG using skeletonized arterial grafts and the T-graft approach is as safe in diabetic patients as in non-diabetic patients.
- The use of RA as a second graft obviates the need for bilateral ITA harvesting.
- This approach offers a viable and safe revascularization strategy for diabetic patients with coronary artery disease.
Background:
The prognostic benefit of arterial grafts appears to be particularly high in patients with diabetes mellitus, but has been limited by availability of grafts and sternal complications. Complete arterial coronary artery bypass grafting (caCABG) using skeletonized grafts, radial arteries (RA) and the T-graft approach may reduce the perioperative risk particularly in the diabetic patient.
Methods:
The perioperative data of 174 diabetic (group I) and 402 non-diabetic patients (group II) who underwent caCABG were studied retrospectively. The operations were performed using bilateral internal thoracic arteries (ITA) (I: 20%; II: 21%; ns) or ITA and RA (I: 80%; II: 79%; ns). Diabetic patients presented with a higher incidence of 3-vessel disease (I: 93%; II: 83%; p<0.05) and a lower left ventricular ejection fraction (I: 55+/-16%; 11:60+/-16%; p<0.05).
Results:
No differences were found regarding need of intraaortic balloon pump (I: 1.7%; II: 2.7%; ns), incidence of myocardial infarction (I: 1.2%; II: 1.7%; ns) and sternal complications (I: 2.3%; II: 1.0%; ns). In-hospital mortality was 1.7%(I) versus 2.2% (II) (p = ns).
Conclusions:
Using skeletonized arterial grafts and the T-graft approach, caCABG in diabetic patients is as safe as in non-diabetics. With the RA as a second graft, bilateral ITA harvesting is avoidable.
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