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Diversity among bovine pestiviruses
C Hamers1, P Dehan, B Couvreur
1Department of Infectious Diseases, Unit of Immunology and Vaccinology, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster, 20 Bat B 43 bis, 4000 Liège, Belgium. chamers@ulg.ac.be
Veterinary Journal (London, England : 1997)
|March 13, 2001
Summary
Bovine viral diarrhoea virus (BVDV) diversity arises from high mutation rates, impacting its pathogenesis and antigenicity. Understanding these variations is crucial for effective BVDV control, diagnostics, and vaccine development.
Area of Science:
- Veterinary Virology
- Molecular Epidemiology
- Immunology
Background:
- Bovine viral diarrhoea virus (BVDV) exhibits significant genetic, antigenic, and pathogenic diversity.
- Emergence of hypervirulent BVDV strains highlights pathogenic differences among isolates.
- RNA virus mutation rates contribute to BVDV diversity.
Purpose of the Study:
- To review the origin and consequences of BVDV diversity.
- To explore BVDV diversity in relation to pathogenesis, biotypes, and antigenic/genetic variations.
- To emphasize the importance of understanding BVDV diversity for disease control.
Main Methods:
- Literature review focusing on BVDV genetic, antigenic, and pathogenic diversity.
- Analysis of mutation impacts on viral genes, particularly those encoding structural proteins.
- Synthesis of information on BVDV pathogenesis, biotypes, and variations.
Main Results:
- Mutations in immunologically important genes have practical implications for BVDV.
- BVDV diversity influences the wide range of disease manifestations.
- Genetic and antigenic variations are key drivers of BVDV diversity.
Conclusions:
- Knowledge of BVDV diversity is essential for understanding disease pathogenesis.
- Monitoring BVDV epidemiology requires understanding its variations.
- Optimizing laboratory tests and vaccines necessitates awareness of BVDV diversity.