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Published on: September 14, 2010
Recurrent pulmonary sarcoidosis in HIV-infected patients receiving highly active antiretroviral therapy
R Lenner1, Z Bregman, A S Teirstein
1Mount Sinai School of Medicine, Mount Sinai-NYU Health, New York, NY, USA. egandrobi@aol.com
Abstract:
HIV infection and sarcoidosis occur in the same age group, but there are only a few reports of the coexistence of the two disorders in the same individual. This infrequent occurrence has been attributed to the paucity of functioning CD4(+) lymphocytes required for granuloma formation in patients with HIV infection. We report two patients with a history of remote sarcoidosis who later in life contracted HIV infection and developed recurrent, progressive pulmonary sarcoidosis while receiving highly active antiretroviral therapy (HAART). Progressive pulmonary sarcoidosis should be added to the differential diagnosis in patients receiving HAART for HIV infection who develop diffuse lung disease with recovery of CD4(+) lymphocyte population.
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