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Topical metronidazole in seborrheic dermatitis--a double-blind study
1Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. dprs@vsnl.com
Objective:
To evaluate the role of topical metronidazole gel in the treatment of seborrheic dermatitis.
Methods:
Forty-four patients with seborrheic dermatitis were enrolled in the study. All topical treatments were stopped for at least 2 weeks before the patients were allocated at random to receive either metronidazole 1% gel or placebo for 8 weeks. The severity score was measured at the initial evaluation, and the patients were followed up at 2-week intervals for 8 weeks. A global evaluation of improvement was done at 8 weeks.
Results:
Thirty-eight patients completed the study; 21 patients in the metronidazole group and 17 patients in the placebo group could be evaluated. There was a statistically significant decrease of the mean score even at week 2; the difference became highly significant at 8 weeks (p < 0.001). On the final evaluation at 8 weeks, 14 patients in the metronidazole group showed marked improvement to complete clearance as compared to only 2 patients having moderate improvement in the placebo group (p < 0.001).
Conclusion:
The present trial has demonstrated the effectiveness of topical 1% metronidazole gel in seborrheic dermatitis.