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Lai-like leptospira from the Andaman Islands

S C Sehgal1, P Vijayachari, L D Smythe

  • 1Regional Medical Research Centre (ICMR), Port Blair, Australia.

The Indian Journal of Medical Research
|March 14, 2001
PubMed
Abstract

Insights

Researchers identified Leptospira serovar lai from a patient in the Andaman Islands. This finding is crucial for understanding leptospirosis transmission and clinical patterns in the region.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Leptospirosis poses a significant public health challenge in the Andaman Islands.
  • Previous etiological data for local leptospirosis cases were limited.

Purpose of the Study:

  • To isolate and identify the causative agent of leptospirosis in human patients from the Andaman Islands.

Main Methods:

  • Leptospira isolate AF61 was obtained from patient blood using Ellinghausen-McCullough-Johnson-Harris (EMJH) medium.
  • Identification involved microscopic agglutination test (MAT), cross agglutination absorption test (CAAT), and monoclonal antibody analysis.

Main Results:

  • The isolate AF61 was confirmed to belong to the *Leptospira* serogroup icterohaemorrhagiae.
  • Cross-agglutination absorption tests and monoclonal antibody analysis indicated a close relationship to serovar lai.

Conclusions:

  • The identified strain AF61 is closely related to *Leptospira* serovar lai, previously linked to pulmonary hemorrhage.
  • The absence of pulmonary symptoms in the patient with strain AF61 suggests potential variations in clinical presentation.
  • Further research is necessary to explore the link between serovars and clinical manifestations, and the prevalence of lai and lai-like strains in Asia.

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