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Related Experiment Videos

[New developments in medical mycology].

H C Korting1, M Schaller

  • 1Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstrasse 9-11, 80337 München.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 14, 2001
PubMed
Summary

Fungal infections, including skin conditions like onychomycosis and tinea pedis, are increasingly common. Effective treatments like terbinafine and novel encapsulated antifungals offer improved outcomes for systemic and superficial mycoses.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Systemic and superficial mycoses are increasingly prevalent.
  • Onychomycosis affects up to 10% of the population, significantly impacting quality of life.
  • Tinea pedis is a key risk factor for erysipelas, and oral candidosis presentation is evolving with new species like Candida dubliniensis.

Purpose of the Study:

  • To review the current landscape of fungal infections, emphasizing increasing incidence and impact.
  • To discuss advancements in antifungal therapies for both systemic and superficial mycoses.
  • To highlight emerging pathogens and virulence factors in candidosis.

Main Methods:

  • Literature review of recent studies on mycoses prevalence and treatment.

Related Experiment Videos

  • Analysis of clinical presentations and risk factors for common fungal infections.
  • Evaluation of novel antifungal agents and their therapeutic potential.

    • Main Results:

    • Onychomycosis is highly prevalent and treatable with agents like terbinafine and itraconazole.
    • Liposomal formulations of amphotericin B and econazole represent significant therapeutic advances.
    • Secreted aspartic proteinases are identified as key virulence factors in Candida infections.

    Conclusions:

    • Current antifungal treatments offer effective options for common mycoses, with ongoing research into novel therapies.
    • Benefit-risk and benefit-cost analyses are crucial for optimal drug selection.
    • Understanding virulence factors like secreted aspartic proteinases may lead to future targeted antimycotic strategies.