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Updated: Aug 17, 2026

Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles
Published on: October 15, 2014
[Morphological observations of tumors in the cardiac conduction system]
1Department of Forensic Pathology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089.
Objective:
To investigate the incidence of tumors in the cardiac conduction system (CCS) and to study their relation to sudden deaths.
Methods:
The CCS from 149 cases of sudden death without extracardiac cause of deaths and those from 737 cases of non-cardiac death were sampled using technique designed by the authors. Routine histological examinations were carried out.
Results:
Tumors in the CCS were found in 12 cases (1.35%). Another case with tumor in the CCS was found in a specimen received for consultation. Of these 13 tumors, 10 were primary benign tumors affecting the CCS, 3 were metastatic tumors. The benign tumors included fibroma, hemangioma, lipomatous hypertrophy of the atrial septum, mesothelioma and rhabdomyoma. 8 of the 10 cases were located in the SAN or AVN. All the metastatic tumors were in the SAN. Of the 13 cases, 3 died suddenly.
Conclusion:
Tumors in the CCS are the smallest tumors which can cause sudden death.
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