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Published on: March 30, 2018
[Detection of Epstein-Barr virus subtypes in Hodgkin's disease]
Objective:
To investigate Epstein-Barr virus (EBV) subtypes in Chinese patients with Hodgkin's disease (HD).
Methods:
113 cases of HD patients with EBV latent membrane protein 1 (LMP-1) and/or EBV encoded small RAN (EBER-1) positive and throat washings from 21 healthy persons were studied for EBV subtypes by polymerase chain reaction (PCR).
Results:
68 HD cases exhibited specific bands, in which 62 cases were EBV type A and 6 cases were EBV type B. 13 of the control washing gave rise to specific bands, of which 11 were EBV type A and 2 of EBV type B.
Conclusion:
The results showed that EBV type A is predominant in Chinese HD patients and healthy individuals.
