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[The relationship between expression of extracellular matrix and clinical pathology of primary lung carcinoma]
1Department of Pathology, Qingdao University Medical College, Qingdao, Shandong 266021.
Objective:
To study the relationship between expression of laminin (LN), fibronectin (FN), collagen IV (Col. IV) and clinical pathology of primary lung cancer.
Methods:
LSAB method was used to detect the expression of LN, FN and Col. IV in 184 cases of lung carcinoma.
Results:
Expression of LN and Col. IV in well and moderately differentiated pulmonary squamous cell carcinoma were both higher than that in poorly differentiated cases (P < 0.01), and marked difference was found between lymph node positive and negative cases (P < 0.05). Obvious difference in the expression of LN and Col. IV was found between the patient groups with squamous cell carcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.01), as was the difference in expression of FN (P < 0.05). Obvious difference in the expression of FN and Col. IV was found between patients groups with adenocarcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.05, 0.01).
Conclusions:
The expression of LN and Col. IV correlated with histological grading and lymph node metastasis of pulmonary squamous cell carcinoma; LN, FN, Col. IV can also be regarded as a parameter for evaluating prognosis of pulmonary squamous cell carcinoma. The expression of FN and Col. IV can be regarded as a parameter for evaluating the prognosis of pulmonary adenocarcinoma.
