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Updated: Aug 10, 2026
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
[Microsatellite instability in gastric carcinoma and intestinal metaplasia]
1Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038.
Objective:
To investigate the role of microsatellite instability (MSI) in the carcinogenesis and development of gastric cancer (GC).
Methods:
MSI was examined in 50 surgically resected gastric cancer specimens and 15 intestinal metaplasia specimens using PCR based methods.
Results:
MSI was detected in 27/50 of GC and 3/15 of intestinal metaplasia at one or more loci. MSI was positive in all three cases of early GC. The incidence of MSI in well differentiated GC (86.6%) was significantly higher than that in poorly differentiated GC (P < 0.05). The frequency of MSI in intestinal type of GC (77.8%) was significantly higher than that in the diffused type (40%, P < 0.05). No significant correlation was found between MSI and age, sex, size, location, lymph node metastasis or clinical stage of GC.
Conclusion:
MSI is an early molecular marker in the carcinogenesis of GC and may play an important role in the development of GC.
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