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Updated: Jul 30, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
Published on: July 14, 2010
NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response
S R Kopf1, R S Benton, R Kalfin
1Munchner Technologiezentrum, IDEA-AG, Frankfurter Ring 193a, 80087, Munich, Germany.
Abstract:
We investigated in rats the effect N(G)-nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system.
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