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Morphine and clonidine activate different K+ channels on rat amygdala neurons
1Department of Pharmaceutical Sciences, Northeastern University, 211 Mugar Building, 360 Huntington Avenue, Boston, MA 02115, USA.
Abstract:
In cell-attached patch-clamp recordings from freshly dissociated neurons of the rat amygdalohippocampal area, clonidine principally activated a 95-pS (picosiemens) inwardly rectifying K+-permeable channel, whereas morphine acting at mu-opioid receptors activated a different 130-pS channel. Clonidine's effects were largely antagonized by the alpha(2)-adrenoceptor antagonist idazoxan, but were poorly mimicked by agmatine. These results partially contradict the prevailing hypothesis that alpha(2) and opioid receptors act through the same ion channel transduction pathways.
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