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Updated: Jun 18, 2026

A Method to Study de novo Formation of Chromatin Domains
Published on: August 23, 2019
DDT -- a novel domain in different transcription and chromosome remodeling factors
1European Molecular Biology Laboratory, 69012 Heidelberg, Germany. doerks@EMBL-HEIDELBERG.DE
Abstract:
Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
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