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[Immunodepressive activity of glycoproteins]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|January 1, 1975
Summary
Cattle glycoprotein fractions from serum, thymus, and liver suppressed immune responses in mice when administered before immunization. These fractions, showing ribonuclease activity, were ineffective when given concurrently or after the antigen.
Area of Science:
- Immunology
- Biochemistry
Context:
- The study investigates the immunomodulatory effects of glycoprotein fractions derived from cattle.
- Focuses on the impact of these fractions on both primary and secondary immune responses.
Purpose:
- To determine the effect of cattle glycoprotein fractions on the immune response in mice.
- To assess the role of ribonuclease activity in the observed immunomodulatory effects.
Summary:
- Glycoprotein fractions isolated from cattle blood serum, thymus, and liver were administered to mice 24 hours prior to immunization with sheep erythrocytes.
- Pre-administration of these fractions significantly depressed both primary and secondary immune responses.
- Concurrent or post-immunization administration of the fractions did not alter the immune response.
- The immunosuppressive fractions exhibited significant ribonuclease activity, suggesting a potential mechanism of action.
Impact:
- Identifies specific cattle glycoprotein fractions with potent immunosuppressive properties.
- Highlights the importance of the timing of administration for immunomodulatory effects.
- Suggests a link between ribonuclease activity and immune suppression, opening avenues for further research into molecular mechanisms.