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Studies of urinary bladder dysfunction in amyloidosis with polyneuropathy.
Acta Medica Scandinavica
|January 1, 1975
Summary
Amyloid polyneuropathy significantly impacts bladder function in men, often leading to increased bladder capacity, urine retention, and diminished voiding efficiency. This study highlights the neurological effects on the urinary system.
Area of Science:
- Urology
- Neurology
- Nephrology
Background:
- Amyloid polyneuropathy is a systemic disease that can affect various organs, including the urinary system.
- Urinary bladder dysfunction is a common but often underdiagnosed complication in patients with amyloidosis.
Purpose of the Study:
- To investigate the urodynamic characteristics of male patients with amyloid polyneuropathy.
- To compare bladder function in patients with amyloidosis to healthy male controls.
Main Methods:
- Cystometry and micturition analysis were performed on eight male patients with amyloid polyneuropathy and eight age-matched male controls.
- Evaluation focused on bladder capacity, detrusor function, flow rate, and bladder wall characteristics.
Main Results:
- Most patients exhibited increased bladder capacity, reduced urgency to void, and common urine retention.
- Detrusor muscle function was impaired in the majority of patients.
- Maximal flow rate was diminished, and resistance to flow was elevated, with some patients showing increased bladder wall rigidity.
Conclusions:
- Amyloid polyneuropathy frequently causes significant bladder dysfunction in men.
- The observed urodynamic changes suggest a neurogenic component affecting bladder emptying and sensation in amyloidosis patients.