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Related Experiment Videos

Sympathetic dysfunction in patients with primary Sjögren's syndrome.

T Mandl1, S V Bornmyr, J Castenfors

  • 1Sjögren's Syndrome Research Centre, Department of Rheumatology, Malmö University Hospital, Sweden.

The Journal of Rheumatology
|March 15, 2001
PubMed
Summary

Patients with primary Sjögren's syndrome exhibit both sympathetic and parasympathetic nervous system dysfunction. Autoimmune factors, specifically anti-SSA/SSB antibodies, may impact blood pressure regulation in these patients.

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Area of Science:

  • Neuroimmunology
  • Autonomic Neurology

Background:

  • Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily affecting exocrine glands.
  • Autonomic nervous system (ANS) dysfunction is increasingly recognized in autoimmune conditions.

Purpose of the Study:

  • To evaluate autonomic nervous system function in patients with primary SS.
  • To correlate ANS findings with clinical and immunological variables in primary SS.

Main Methods:

  • Assessed ANS function using finger skin blood flow (vasoconstrictory index), deep-breathing (expiration/inspiration ratio), and tilt table tests.
  • Compared results from 30 primary SS patients with age-matched controls.

Main Results:

  • Primary SS patients demonstrated impaired sympathetic (increased vasoconstrictory index) and parasympathetic (decreased expiration/inspiration ratio) function.

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  • Abnormal blood pressure responses during tilt table testing were observed, particularly in patients with anti-SSA/SSB antibodies.
  • No significant correlations were found between ANS measures and ophthalmologic or oral assessments.

    • Conclusions:

    • Primary SS is associated with significant sympathetic and parasympathetic nervous system dysfunction.
    • Immunological factors, such as anti-SSA/SSB antibodies, appear to influence cardiovascular regulation in primary SS.