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Updated: Oct 9, 2026

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
Published on: February 3, 2018
Nuclear methods to characterize biomaterials
J L Irigaray1, H Oudadesse, V Brun
1Laboratoire de physique corpusculaire de Clermont-Ferrand, INV2P3/CNRS--Université Blaise Pascal, Aubiere, France. irigaray@clermont.in2p3.fr
Abstract:
Techniques using X-rays are often used to study biomaterials fields. However, when one is interested by quantitative and very sensitive measurements, it is valuable to develop nuclear instruments and methods, in addition and complement with others. Fast neutron activation is appropriate for non-destructive analysis. Thermal neutron activation can evaluate trace elements as a reference. Proton-induced X-rays emission is applied to cartography of heavy elements. If necessary, proton-induced gamma-rays emission and charged particles scattering are suitable for evaluation and cartography of light elements. Radioactivated nuclei and labelled molecules can tag element transfers and biofunctionality. In our work, these methods are related to biomaterials field.
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