[Effects of bioflavonoids on the toxicity of T-toxin in rats. A morphological study]

Subacute toxicity of T-2 toxin in rats was characterized by a primary defeat of liver, thymus, spleen and intraorgan arteries. In 75% of animals found out increase of the size and adipose infiltration of a liver, in all animals--reduction of the size of thymus (sharp) and spleen (moderate) and pronounced hypoplasia of lymphoid tissue. In the majority of rats vacuolation of cytoplasma of smooth-muscular walls of coronary and intrarenal arteries was revealed. In animals received T-2 toxin against a background of a diet with addition a flour from seeds of milk thistle with high contents of flavonoids, described morphological changes were expressed to a lesser degree and were observed less often. Moderate periportal adipose infiltration of a liver was revealed in 30% of animals, occupancy by cells of lymphoid tissue increased, the quantity and sizes of vacuoles in walls of vessels decreased.