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Related Experiment Videos

Clindamycin-associated colitis.

J L Unger, W E Penka, C Lyford

    The American Journal of Digestive Diseases
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Clindamycin-associated colitis can cause prolonged diarrhea and mucosal damage weeks after antibiotic discontinuation. Physicians should consider this diagnosis in patients experiencing diarrhea during clindamycin therapy.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Clindamycin is an antibiotic with known gastrointestinal side effects.
    • Antibiotic-associated colitis is a serious condition with potential for significant morbidity and mortality.

    Purpose of the Study:

    • To report four cases of clindamycin-associated colitis observed at Kansas University Medical Center.
    • To highlight the clinical presentation and diagnostic considerations for this adverse drug reaction.

    Main Methods:

    • Case series reporting on four patients who developed colitis after clindamycin treatment.
    • Review of clinical data including onset of symptoms, duration, and endoscopic findings.

    Main Results:

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  • All four patients experienced diarrhea 7-14 days after starting clindamycin.
  • Diarrhea persisted for weeks even after discontinuing the antibiotic.
  • Endoscopic examination revealed mucosal changes ranging from focal ulceration to pseudomembrane formation.

    • Conclusions:

    • Diarrhea in patients receiving clindamycin should prompt consideration of antibiotic-induced colitis.
    • Early recognition and diagnosis are crucial for managing this potentially severe condition.