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Penicillin-resistant Streptococcus pneumoniae endocarditis: a case report and review

M Siegel1, J Timpone

  • 1Division of Infectious Diseases, Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 15, 2001
PubMed

Insights

Penicillin-resistant Streptococcus pneumoniae endocarditis is rare but emerging. This case highlights successful treatment of bivalvular PRSP endocarditis with vancomycin and trovafloxacin, underscoring treatment challenges.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Microbiology

Background:

  • Streptococcus pneumoniae is an uncommon cause of endocarditis, especially in the postantibiotic era.
  • The rise of antibiotic-resistant Pneumococcus strains has led to isolated cases of penicillin-resistant S. pneumoniae (PRSP) endocarditis.

Observation:

  • This report details a rare instance of bivalvular endocarditis caused by PRSP.
  • The patient's infection involved multiple heart valves, complicating the clinical picture.

Findings:

  • The case demonstrates successful management of PRSP endocarditis using a combination of vancomycin and trovafloxacin.
  • Literature review indicates a need for effective therapeutic strategies against resistant pneumococcal endocarditis.

Implications:

  • This case contributes to understanding the clinical presentation and treatment of antibiotic-resistant bacterial endocarditis.
  • Further research into optimal treatment regimens for PRSP endocarditis is warranted given the increasing resistance patterns.

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