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Related Experiment Videos

Both central command and exercise pressor reflex reset carotid sinus baroreflex.

S A McIlveen1, S G Hayes, M P Kaufman

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, California 95616, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|March 15, 2001
PubMed
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Central command and the exercise pressor reflex can reset the carotid baroreflex in cats. These reflexes alter aortic pressure and heart rate responses without changing the baroreflex curve

Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Exercise Physiology

Background:

  • The carotid baroreflex is a critical regulator of blood pressure and heart rate.
  • The influence of central command and exercise reflexes on baroreflex function remains incompletely understood.

Purpose of the Study:

  • To investigate whether central command, the exercise pressor reflex, or the muscle mechanoreceptor reflex reset the carotid baroreflex in decerebrate cats.

Main Methods:

  • Carotid baroreceptors were isolated and stimulated with controlled pulsatile pressure in decerebrate cats.
  • Carotid baroreflex function curves for aortic pressure, heart rate, and renal vascular conductance were determined.
  • Central command (via MLR stimulation), exercise pressor reflex, and muscle mechanoreceptor reflex were evoked.

Related Experiment Videos

Main Results:

  • Central command, exercise pressor reflex, and muscle mechanoreceptor reflex each caused an upward shift in the carotid baroreflex function curves for aortic pressure and heart rate.
  • These maneuvers did not alter the slope of the carotid baroreflex function curves.

Conclusions:

  • Central command originating from the mesencephalic locomotor region (MLR) resets the carotid baroreflex.
  • The exercise pressor reflex also resets the carotid baroreflex.
  • These findings elucidate neural control mechanisms of cardiovascular regulation during exercise.