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Related Experiment Videos

Ambient temperature modulates hypoxic-induced changes in rat body temperature and activity differentially.

B Bishop1, G Silva, J Krasney

  • 1State University of New York at Buffalo, Department of Physiology and Biophysics, Sherman Hall/South Campus, Buffalo, NY 14214, USA. bpbishop@ACSU.buffalo.edu

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|March 15, 2001
PubMed
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Ambient temperature significantly influences rat responses to hypoxia. Lower temperatures prevent hyperthermia and may protect the brain from pathology during oxygen deprivation.

Area of Science:

  • Physiology
  • Environmental Science
  • Neuroscience

Background:

  • Hypoxia abolishes circadian rhythms of body temperature and activity in rats acclimated to 29°C.
  • Hypoxia also induces brain pathology and significant changes in body temperature and activity.

Purpose of the Study:

  • To investigate the role of ambient temperature (T(a)) in hypoxic responses.
  • To determine how T(a) affects body temperature (T(b)) and activity (L(a)) during hypoxia.

Main Methods:

  • Rats were acclimated to 25°C or 21°C.
  • Body temperature and activity were monitored via telemetry for 48 hours on air, followed by 63 hours on 10% oxygen.

Main Results:

  • Hypoxic body temperature decline was inversely proportional to T(a).

Related Experiment Videos

  • Body temperature recovery after hypothermia was directly proportional to T(a).
  • Hyperthermia observed at 29°C did not occur at 21°C or 25°C; activity depression was least at 21°C.

    • Conclusions:

    • Ambient temperature is a key factor in the body temperature and activity responses to hypoxia.
    • Absence of hyperthermia at lower ambient temperatures may offer neuroprotection against hypoxic injury.