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Summary
Nalidixic acid can cause sun-induced skin blisters in some individuals. These reactions may persist even after discontinuing the medication, indicating complex photosensitivity.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Cutaneous adverse drug reactions can manifest as photosensitivity.
- Nalidixic acid is an antibiotic known to potentially cause skin reactions.
Purpose of the Study:
- To report and analyze cases of cutaneous blistering associated with nalidixic acid exposure.
- To investigate the underlying mechanisms of photosensitivity reactions to nalidixic acid.
Main Methods:
- Case report of two patients experiencing cutaneous blisters after sun exposure while on nalidixic acid.
- Phototesting to assess ultraviolet (UV) radiation sensitivity in one patient.
Main Results:
- Recurrent blistering occurred despite cessation of nalidixic acid and sun exposure.
- Phototesting revealed abnormal sensitivity to both short and long wavelength UV spectra.
Conclusions:
- The findings suggest a photosensitivity reaction to nalidixic acid.
- The reaction exhibits characteristics of both photoallergy and phototoxicity, despite a low incidence.