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Complete genomic sequence of Pasteurella multocida, Pm70.

B J May1, Q Zhang, L L Li

  • 1Department of Veterinary Pathobiology, University of Minnesota, St. Paul, MN 55108, USA.

Proceedings of the National Academy of Sciences of the United States of America
|March 15, 2001
PubMed
Summary

The complete genome of the avian pathogen Pasteurella multocida (Pm70) was sequenced, revealing insights into its evolution and virulence factors. This study provides a foundation for understanding its role as a pathogen.

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Area of Science:

  • Microbiology
  • Genomics
  • Evolutionary Biology

Background:

  • Pasteurella multocida is a significant avian pathogen with a broad host range.
  • Understanding its genomic structure is crucial for developing effective control strategies.

Purpose of the Study:

  • To present the complete genome sequence of the avian Pasteurella multocida Pm70 clone.
  • To conduct preliminary functional analyses, including evolutionary and virulence-associated gene identification.

Main Methods:

  • Whole-genome sequencing of Pasteurella multocida Pm70.
  • Comparative genomic analysis with Haemophilus influenzae and Escherichia coli.
  • In silico and whole-genome microarray analyses for gene function prediction.

Main Results:

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  • The Pm70 genome is a 2.26 Mb circular chromosome with 2,014 coding regions.
  • Phylogenetic analysis suggests divergence from H. influenzae ~270 million years ago.
  • Identified novel virulence-associated genes and over 50 genes involved in iron acquisition.

Conclusions:

  • The complete genome sequence provides a valuable resource for studying Pasteurella multocida pathogenesis.
  • Identified potential virulence factors and iron metabolism genes offer targets for future research.
  • This work lays the groundwork for understanding host specificity and developing interventions.