Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Appendectomy and protection against ulcerative colitis.

R E Andersson1, G Olaison, C Tysk

  • 1Department of Surgery, County Hospital Ryhov, Jönköping, Sweden. roland.andersson@ryhov.ltjkpg.se

The New England Journal of Medicine
|March 15, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When and how to Screen!

Journal of internal medicine·2020
Same author

Decrease in primary but not in secondary abdominal surgery for Crohn's disease: nationwide cohort study, 1990-2014.

The British journal of surgery·2020
Same author

Major Variation in the Incidence of Appendicitis Before, During and After Pregnancy: A Population-Based Cohort Study.

World journal of surgery·2020
Same author

RIFT study and management of suspected appendicitis.

The British journal of surgery·2020
Same author

Increased risk for tooth extraction in primary hyperparathyroidism and hypercalcemia: a population study.

Clinical oral investigations·2019
Same author

Validation of the Norwegian survival prediction model in trauma (NORMIT) in Swedish trauma populations.

The British journal of surgery·2019
Same journal

Sparganosis.

The New England journal of medicine·2026
Same journal

Caring for an Aging America - The Looming Crisis of the Long-Term-Care Workforce.

The New England journal of medicine·2026
Same journal

For Those Left Behind.

The New England journal of medicine·2026
Same journal

Colliding Forces - The Aging of the Baby Boom Generation and Contracting Nursing-Home Supply.

The New England journal of medicine·2026
Same journal

Mandated State-Level Surveillance of Assisted Reproductive Technology - An Emerging Threat in the United States.

The New England journal of medicine·2026
Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026
See all related articles

Appendectomy for appendicitis or mesenteric lymphadenitis before age 20 is linked to a lower risk of ulcerative colitis. Surgery for nonspecific abdominal pain showed no protective effect against ulcerative colitis.

Area of Science:

  • Gastroenterology
  • Surgical Outcomes
  • Inflammatory Bowel Disease

Background:

  • A history of appendectomy is uncommon in ulcerative colitis (UC) patients.
  • This suggests appendectomy may have a protective effect or that appendicitis and UC are alternative inflammatory responses.
  • The inverse relationship between appendectomy and UC requires further investigation.

Purpose of the Study:

  • To investigate the association between appendectomy and the subsequent risk of developing ulcerative colitis.
  • To determine if the reason for appendectomy influences the risk of ulcerative colitis.
  • To explore age as a factor in the relationship between appendectomy and ulcerative colitis.

Main Methods:

  • A cohort study involving 212,963 patients who underwent appendectomy before age 50 (1964-1993).

Related Experiment Videos

  • Matched controls were identified from Swedish registers and census data.
  • The cohort was followed until 1995 for ulcerative colitis diagnosis.

    • Main Results:

    • Appendectomy for appendicitis (perforated or non-perforated) or mesenteric lymphadenitis was associated with a reduced risk of ulcerative colitis (adjusted hazard ratios ranging from 0.57 to 0.76).
    • Appendectomy for nonspecific abdominal pain did not alter the risk of ulcerative colitis (adjusted hazard ratio 1.06).
    • The protective association between appendectomy for appendicitis and ulcerative colitis was significant only for surgeries performed before age 20.

    Conclusions:

    • Appendectomy for inflammatory conditions like appendicitis or lymphadenitis, particularly before age 20, is linked to a lower risk of developing ulcerative colitis.
    • Appendectomy for nonspecific abdominal pain does not confer a reduced risk of ulcerative colitis.
    • The findings suggest a potential role for early appendectomy in modifying ulcerative colitis risk.