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Related Experiment Videos

HATs on and beyond chromatin.

H Chen1, M Tini, R M Evans

  • 1Department of Biological Chemistry, UC Davis Cancer Center/Basic Science Program, University of California at Davis, Sacramento, California 95817, USA. hwzchen@ucdavis.edu

Current Opinion in Cell Biology
|March 15, 2001
PubMed
Summary

Histone acetylation regulates gene transcription and DNA repair. Emerging research shows protein acetylation, mediated by histone acetyltransferases, is a key cellular signaling mechanism, potentially rivaling phosphorylation.

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Biochemistry

Background:

  • Histone acetylation is a known regulator of gene transcription.
  • Histone acetyltransferases (HATs) are increasingly implicated in DNA replication, recombination, and repair.
  • Protein acetylation regulates diverse molecular interactions.

Purpose of the Study:

  • To highlight the expanding roles of histone acetyltransferases beyond transcriptional regulation.
  • To emphasize the significance of protein acetylation in cellular signaling pathways.

Main Methods:

  • Literature review of recent advances in histone acetylation research.
  • Analysis of emerging data on histone acetyltransferase substrates and functions.

Main Results:

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  • Histone acetyltransferases are involved in crucial DNA processes.
  • Acetylation of various proteins modulates molecular interactions.
  • Protein acetylation is emerging as a major cellular regulatory mechanism.

Conclusions:

  • Protein acetylation, mediated by HATs, plays diverse roles in cellular processes.
  • Acetylation is a critical signaling mechanism comparable to phosphorylation.