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Thyroid morphology in lethal non-thyroidal illness: a post-mortem study.

F E De Jongh1, A C Jöbsis, J W Elte

  • 1Department of Internal Medicine, St Franciscus Gasthuis, Rotterdam, The Netherlands.

European Journal of Endocrinology
|March 15, 2001
PubMed
Summary
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Non-thyroidal illness (NTI) causes smaller thyroid follicles and lower thyroid weight in chronically ill patients. This study examined thyroid morphology in lethal non-thyroidal disease cases.

Area of Science:

  • Endocrinology
  • Pathology
  • Autopsy Studies

Background:

  • Non-thyroidal illness (NTI) is linked to altered thyroid hormone metabolism.
  • Morphological changes in the thyroid gland during NTI are not well understood.

Purpose of the Study:

  • To investigate and describe thyroid gland morphology in patients with lethal non-thyroidal disease.

Main Methods:

  • Autopsy study of 267 cases, excluding those with pre-existing thyroid disorders.
  • Clinical data analyzed from medical records of chronic illness, intensive care, and sudden death groups.
  • Thyroid histology assessed semi-quantitatively based on follicular size and gland occupation.

Main Results:

  • Mean thyroid weight was significantly lower in chronically ill patients (19.9g) compared to intensive care (25.7g) and sudden death (26.0g) groups.

Related Experiment Videos

  • Grade III histology (large follicles) was prevalent in chronically ill (30/75) and intensive care (17/64) patients.
  • Grade I histology (small follicles) was significantly more common in sudden death subjects (33/35) than in the other groups.

    • Conclusions:

    • NTI is associated with reduced thyroid follicular size.
    • Lower thyroid weight accompanies reduced follicular size in chronically ill patients.
    • Thyroid weight reduction was not significant in intensive care patients despite follicular size changes.