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Updated: Aug 5, 2026

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
Published on: July 10, 2018
Corneal deposition after high-dose chlorpromazine hydrochloride therapy
S K Webber1, Y Domniz, G L Sutton
1Sydney Refractive Surgery Centre, Chatswood, NSW, Australia.
Purpose:
To report a case of dermal and ocular changes after prolonged use of high-dose chlorpromazine hydrochloride therapy.
Method:
This case report includes clinical history, clinical findings, and photographic images of ocular and dermal changes. RESULTS. Chlorpromazine therapy in a cumulative dosage exceeding 1,100 g resulted in dramatic skin discoloration and multiple crystalline deposits in both corneas. Anterior capsular opacities were binocularly present. These changes were sufficient to cause reduction in visual acuity.
Conclusions:
Chlorpromazine deposition at high levels can cause reduction in visual acuity and significant skin discoloration.
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