Soft-tissue augmentation with Fascian

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Tissue Engineering

Background:

• Injectable soft-tissue fillers are widely used for repair and augmentation.
• Previous research established the host fibroblast and collagen replacement of particulate freeze-dried grafts (pFGs).
• Existing fillers have limitations regarding storage, allergenicity, and application versatility.

Purpose of the Study:

• To introduce Fascian, an injectable formulation of pFGs, for soft-tissue repair and augmentation.
• To highlight the advantages of Fascian over current soft-tissue substitutes.
• To describe the material properties and potential applications of Fascian.

Main Methods:

• Fascian is prepared from screened human donor tissue into an injectable formulation.
• The material is freeze-dried, eliminating the need for refrigeration.
• Fascian is available in multiple particle sizes, including those compatible with a 27-gauge needle.

Main Results:

• Fascian demonstrates low allergenicity, negating the need for test implantation.
• Its availability in various particle sizes allows for treatment of both fine defects and larger lesions.
• The tissue particulation process does not alter inherent graft properties, maintaining its biological function.

Conclusions:

• Fascian offers a convenient and versatile option for soft-tissue repair and augmentation.
• The material's properties support its use in a wide range of clinical scenarios.
• Fascian appears to facilitate the natural collagen replacement process observed in larger grafts.