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Related Experiment Videos

Hepatic resection and gastric secretion.

J A Pinkerton, R B Adkins, W G Gobbel

    The American Surgeon
    |June 11, 1975
    PubMed
    Summary
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    This study refutes the theory linking abnormal liver function after liver resection to increased gastric acid. Experiments show no evidence of "physiologic shunting" causing gastric acid hypersecretion.

    Area of Science:

    • Gastroenterology
    • Hepatology
    • Surgical Research

    Background:

    • Liver resection can lead to changes in liver function.
    • The role of post-resection liver function in gastric acid regulation is not fully understood.
    • Previous theories proposed
    • physiologic shunting
    • as a mechanism for gastric acid hypersecretion.

    Purpose of the Study:

    • To investigate the relationship between abnormal liver function post-hepatectomy and gastric acid secretion.
    • To test the hypothesis that "physiologic shunting" of histamine or other gastric secretagogues causes gastric acid hypersecretion after liver resection.

    Main Methods:

    • Hepatic resection in experimental models (specifics not detailed in abstract).

    Related Experiment Videos

  • Assessment of liver function in remaining liver tissue.
  • Measurement of gastric acid secretion.
  • Evaluation for evidence of histamine or other gastric secretagogue shunting.

    • Main Results:

    • Experimental results contradict the proposed theory.
    • No evidence found to support that abnormal liver function after 60-70% hepatic resection causes gastric acid hypersecretion.
    • The
    • physiologic shunting
    • theory was not supported by the findings.

    Conclusions:

    • Abnormal liver function following significant hepatic resection does not appear to cause gastric acid hypersecretion via "physiologic shunting".
    • The proposed mechanism of histamine or other gastric secretagogue shunting is refuted by these experimental findings.