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Updated: Oct 9, 2026
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Design, synthesis and preliminary biological evaluation of a focused combinatorial library of stereodiverse
N Moitessier1, S Dufour, F Chrétien
1Groupe SUCRES, Unité Mixte 7565 CNRS-Université Henri Poincaré-Nancy 1, Nancy-Vandoeuvre, France.
Bioorganic & Medicinal Chemistry
|March 16, 2001
Abstract:
A focused combinatorial library of 126 mimetics of the RGD sequence based on sugar scaffolds have been rationally constructed using molecular modeling, with a particular emphasis on the stereodiversity of the library. A liquid phase, mix and divide synthesis was used, active compounds being identified by using orthogonal libraries and recursive deconvolution strategies.
