Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone: current and future therapeutic applications.

R D Murray1, S M Shalet

  • 1Department of Endocrinology, Christie Hospital, NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK.

Expert Opinion on Pharmacotherapy
|March 16, 2001
PubMed
Summary

Growth hormone (GH) replacement therapy improves body composition and quality of life in adults with GH deficiency (GHD). However, its use in other conditions requires further research due to mixed results and safety concerns.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-operative volumes following endoscopic surgery for non-functioning pituitary macroadenomas are predictive of further intervention, but not endocrine outcomes.

BMC endocrine disorders·2021
Same author

When Can We Discharge Differentiated Thyroid Cancer Patients Who Present With High-Risk Disease and Subsequently Have an Excellent Response to Treatment?

Clinical oncology (Royal College of Radiologists (Great Britain))·2019
Same author

Can We Discharge Dynamically Risk-Stratified Low-Risk (Excellent Response to Treatment) Thyroid Cancer Patients After 5 Years of Follow-Up?

Clinical oncology (Royal College of Radiologists (Great Britain))·2019
Same author

Report on a Case of Death from Severe Internal Injuries in Which a Diseased Spleen Escaped Rupture.

The Indian medical gazette·2017
Same author

Malarial Paralysis and Apoplexy.

The Indian medical gazette·2017
Same author

Case of Strangulated Inguinal Hernia, with Gangrene of the Gut: Recovery, with Artificial Anus.

The Indian medical gazette·2017

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Pharmacology

Background:

  • Recombinant DNA technology advanced growth hormone (GH) availability in the mid-1980s.
  • Adults with GH deficiency (GHD) exhibit adverse body composition, reduced physical function, and impaired quality of life.
  • GH possesses anabolic, lipolytic, and antinatriuretic properties, suggesting therapeutic potential.

Purpose of the Study:

  • To evaluate the efficacy of GH replacement therapy in adults with GHD.
  • To explore the potential therapeutic applications of GH in various disease states.
  • To assess the safety and efficacy of GH in non-GHD conditions.

Main Methods:

  • Review of studies investigating GH at physiological and pharmacological dosages.
  • Analysis of placebo-controlled trials and uncontrolled studies.

Related Experiment Videos

  • Consideration of recent safety data regarding GH use in critically ill patients.

    • Main Results:

    • GH replacement in GHD adults reverses adverse body composition and improves well-being, energy, and mood.
    • Initial studies suggested benefits in conditions like frailty and osteoporosis, but placebo-controlled trials showed less dramatic effects.
    • High-dose GH in critically ill patients was associated with increased mortality.

    Conclusions:

    • GH replacement therapy is effective for GHD adults, improving physical and psychological parameters.
    • Therapeutic use of GH beyond GHD replacement requires further investigation due to inconsistent efficacy and safety concerns.
    • Current evidence supports GH use primarily for replacement therapy and ongoing research.