Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokine gene-engineered vaccines.

G Forni1, K Boggio

  • 1Department of Clinical and Biological Sciences, University of Turin, Ospedale San Luigi Gonzaga, 10043 Orbassano, Italy. forni@pasteur.sluigi.unito.it

Current Opinion in Molecular Therapeutics
|March 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Piezosurgical partial ostectomy of the incisive bone for an ossifying fibroma removal in a 4-year-old Warmblood gelding.

Equine veterinary journal·2026
Same author

New insights into mitochondrial segregation from the Doubly Uniparental Inheritance system in bivalves.

BMC biology·2025
Same author

Headshaking associated with a unique presentation of guttural pouches infection and otitis media in a Quarter Horse stallion: diagnosis, medical treatment and outcome.

Journal of equine veterinary science·2025
Same author

Little red riding hood in the social forest. Online grooming as a public health issue: a narrative review.

Annali di igiene : medicina preventiva e di comunita·2020
Same author

Randomised clinical trial: sofosbuvir and ledipasvir in patients with transfusion-dependent thalassaemia and HCV genotype 1 or 4 infection.

Alimentary pharmacology & therapeutics·2017
Same author

Strategies for cell-mediated immunotherapy of cancer: killing or help?

Immunology today·2014

Cytokine-based cancer vaccines induce immune memory to prevent tumor growth. While safe in clinical trials, this approach is less effective against established tumors.

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Cytokines are key regulators of immune responses.
  • Cancer vaccines aim to stimulate the immune system to fight tumors.
  • Cytokine-gene engineered therapies offer a novel approach to cancer vaccination.

Purpose of the Study:

  • To evaluate the efficacy of cytokine-based cancer vaccines in inducing immune memory.
  • To assess the potential of these vaccines in preventing tumor growth and treating metastases.
  • To determine the safety and applicability of cytokine-based cancer vaccines in clinical settings.

Main Methods:

  • Experimental vaccination in rodents and humans using cytokine-gene engineered tumor cells, fusion proteins, and DNA.
  • Assessment of induced immune memory against tumors, including poorly immunogenic types.

Related Experiment Videos

  • Clinical trials focused on patients with advanced-stage tumors.

    • Main Results:

    • Vaccination strategies successfully induced significant immune memory.
    • This immune memory demonstrated efficacy in preventing tumor growth and curing initial metastases.
    • The approach showed limited effectiveness against established tumors.
    • Clinical trials indicated that the cytokine-based cancer vaccine approach is safe.

    Conclusions:

    • Cytokine-based cancer vaccines are a safe and promising strategy for inducing anti-tumor immune memory.
    • These vaccines show potential for preventing tumor development and treating early-stage disease.
    • Further research is needed to enhance efficacy against established and advanced-stage cancers.