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Profile of moxifloxacin drug interactions

H Stass1, D Kubitza

  • 1Institute of Clinical Pharmacology, Bayer AG, Building 470, D-42096 Wuppertal, Germany. Heino.Stass.hs@bayer-ag.de

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 16, 2001
PubMed

Insights

Moxifloxacin absorption is not affected by food or ranitidine but can be reduced by multivalent cations. This fluoroquinolone shows minimal drug interactions, enhancing its safe clinical use.

Area of Science:

  • Pharmacology
  • Drug Interactions
  • Antibiotics

Background:

  • Understanding drug interactions is crucial for safe and effective medication use.
  • Moxifloxacin is a widely used fluoroquinolone antibiotic.

Purpose of the Study:

  • To investigate the drug interaction profile of moxifloxacin.
  • To assess the impact of common co-administered drugs and food on moxifloxacin pharmacokinetics.

Main Methods:

  • Oral administration of moxifloxacin in the presence of ranitidine, food, and drugs containing multivalent cations.
  • Pharmacokinetic analysis of moxifloxacin with digoxin, theophylline, glyburide, warfarin, and oral contraceptives.
  • Assessment of moxifloxacin's interaction with probenecid regarding its elimination.

Main Results:

  • Moxifloxacin absorption was unaffected by ranitidine or food.
  • Multivalent cations (Mg++, Al+++, Fe++) impaired moxifloxacin absorption, but Ca++ did not.
  • No clinically significant pharmacokinetic interactions were observed with digoxin, theophylline, glyburide, warfarin, or oral contraceptives.
  • Probenecid did not affect moxifloxacin elimination.

Conclusions:

  • Moxifloxacin exhibits a favorable drug interaction profile.
  • The absence of cytochrome P-450 mediated interactions contributes to its safety.
  • Moxifloxacin's predictable interaction profile supports its advantageous clinical application.

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